Semax Dosage Calculator

Semax is a synthetic heptapeptide derived from ACTH (adrenocorticotropic hormone), specifically from the fragment ACTH(4-7). It was developed in Russia at the Institute of Molecular Genetics and is approved in Russia and Ukraine for use in cognitive disorders, stroke treatment, and neuroprotection. Outside these countries, Semax is researched as a nootropic and neuroprotective agent; it is not FDA-approved.

Semax's primary researched mechanisms include increasing BDNF (brain-derived neurotrophic factor) levels, modulating dopamine and serotonin systems, and providing neuroprotective effects. Research has explored its potential for cognitive enhancement, memory improvement, attention, and neurological recovery after injury.

Unlike stimulants, Semax is thought to work by supporting the brain's natural plasticity mechanisms rather than simply increasing neurotransmitter activity. Anecdotal reports in research communities describe increased focus without stimulant-like jitteriness; controlled human evidence outside Russia remains limited.

Semax is supplied in 10mg vials. Using 2ml of BAC water gives 5,000 mcg/ml. Common injectable research doses range from 200–600mcg, 1–2 times daily. It has a short half-life of approximately 20 minutes, though neurological effects are reported to persist longer. It can also be administered intranasally.

Every result comes from the same three formulas used for any lyophilized peptide: concentration (mcg/ml) = vial mg × 1,000 ÷ BAC water ml; injection volume (ml) = desired dose mcg ÷ concentration; syringe units = injection volume ml × 100 on a U-100 syringe.

For the preset Semax setup on this page: a 10mg vial mixed with 2ml of bacteriostatic water gives a concentration of 5,000 mcg/ml. A 200mcg dose then needs 0.04ml, which is 4 units on a 100-unit insulin syringe.

The full methodology, with worked examples and the assumptions behind each formula, is on the methodology page.

The arithmetic itself is exact — the same inputs always produce the same output. Real-world accuracy depends on things outside the calculator: actual vial contents can vary slightly from the labeled amount within manufacturing tolerance, the BAC water volume should be measured carefully, and syringe readings are taken at the bottom edge of the plunger. Reconstituted peptides also degrade over time (the common guidance is to use within about 28 days refrigerated), which the math does not model. This tool does arithmetic only — it does not recommend doses, and it is not medical advice.