Tesamorelin Dosage Calculator
Calculate tesamorelin injection volumes. Pre-filled for a 2mg vial with 0.5ml BAC water (4,000 mcg/ml). Full 2mg dose = 0.5ml = 50 units.
Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) that is FDA-approved (as Egrifta) for HIV-associated lipodystrophy. It stimulates pituitary GH release and is studied for its ability to reduce visceral adipose tissue. Unlike GLP-1 peptides, it acts primarily on fat distribution rather than appetite.
For a 2mg Tesamorelin vial: add 0.5ml of bacteriostatic water → concentration is exactly 4000 mcg/ml. The FDA-labeled 2000mcg (2mg) daily dose = 0.50ml (50 units) on a 100-unit syringe.
Dose Reference Table
Pre-calculated for a 2mg vial + 0.5ml BAC water = 4,000 mcg/ml concentration. Using a 100-unit (1ml) insulin syringe.
| Dose | Inject Volume (ml) | Syringe Units |
|---|---|---|
| 500mcg | 0.125 ml | 12.5 units |
| 1000mcg (1mg) | 0.250 ml | 25 units |
| 1500mcg (1.5mg) | 0.375 ml | 37.5 units |
| 2000mcg (2mg) | 0.500 ml | 50 units |
About Tesamorelin
Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) that is FDA-approved under the brand name Egrifta for the treatment of HIV-associated lipodystrophy (abnormal fat distribution). It consists of the full 44 amino acid sequence of GHRH with a trans-3-hexenoic acid group added to stabilize it against enzymatic degradation.
In HIV-associated lipodystrophy, tesamorelin is used to reduce visceral (abdominal) fat accumulation. It works by stimulating the pituitary to release endogenous GH, which then promotes lipolysis in visceral adipose tissue. Beyond its FDA-approved indication, tesamorelin has been studied for body composition, cognitive function, and cardiovascular risk markers.
Tesamorelin is supplied in 2mg vials. It is reconstituted with 0.5ml of sterile diluent (or bacteriostatic water) provided with the kit, giving a concentration of 4,000 mcg/ml. The FDA-approved dose is 2mg (the full vial) administered once daily via subcutaneous injection into the abdomen.
Tesamorelin has a very short half-life of approximately 26 minutes, necessitating daily administration. It is typically injected at consistent times each day, often in the morning or at bedtime.
How this calculator works
Every result comes from the same three formulas used for any lyophilized peptide: concentration (mcg/ml) = vial mg × 1,000 ÷ BAC water ml; injection volume (ml) = desired dose mcg ÷ concentration; syringe units = injection volume ml × 100 on a U-100 syringe.
For the preset Tesamorelin setup on this page: a 2mg vial mixed with 0.5ml of bacteriostatic water gives a concentration of 4,000 mcg/ml. A 2,000mcg dose then needs 0.50ml, which is 50 units on a 100-unit insulin syringe.
The full methodology, with worked examples and the assumptions behind each formula, is on the methodology page.
Accuracy & limitations
The arithmetic itself is exact — the same inputs always produce the same output. Real-world accuracy depends on things outside the calculator: actual vial contents can vary slightly from the labeled amount within manufacturing tolerance, the BAC water volume should be measured carefully, and syringe readings are taken at the bottom edge of the plunger. Reconstituted peptides also degrade over time (the common guidance is to use within about 28 days refrigerated), which the math does not model. This tool does arithmetic only — it does not recommend doses, and it is not medical advice.
Last reviewed: September 2026 · Content, formulas and sources checked by Kanika